Retinogeniculate connections: A balancing act between connection specificity and receptive field diversity.

Retinogeniculate connections are one of the most striking examples of connection specificity within the visual pathway. In almost every connection there is one dominant afferent cell per geniculate cell, and both afferent and geniculate cells have very similar receptive fields. The remarkable specificity and strength of retinogeniculate connections have inspired comparisons of the lateral geniculate nucleus (LGN) with a simple relay that connects the retina with the visual cortex. However, because each retinal ganglion cell diverges to innervate multiple cells in the LGN, most geniculate cells must receive additional inputs from other retinal afferents that are not the dominant ones. These additional afferents make weaker connections and their receptive fields are not as perfectly matched with the geniculate target as the dominant afferent. We argue that these 'match imperfections' are important to create receptive field diversity among the cells that represent each point of visual space in the LGN. We propose that the convergence of dominant and weak retinal afferents in the LGN multiplexes the array of retinal ganglion cells by creating receptive fields that have a richer range of positions, sizes and response time courses than those available at the ganglion cell layer of the retina.

Hippocampal dysfunction during aging II: deficits on the radial-arm maze.

Middle-aged and aged rats received dorsal hippocampal lesions before performance was evaluated on the radial-arm maze. The maze task contained simultaneous spatial working memory and visually cued reference memory components. Both middle-aged and aged rats that received lesions committed more errors of both types than sham-operated rats. Moreover, an age-related deficit was found for working and reference memory errors. After 14 sessions of training, a probe session revealed that: (a) middle-aged sham rats relied on spatial cues, (b) middle-aged lesioned rats employed the visual cues at the ends of the maze arms, (c) aged sham rats relied predominately on spatial information, (d) aged lesioned rats could not use spatial information or the visual cues at the ends of the maze arms. The additive effect of lesion and age suggests continued reliance on the hippocampus despite age-related deficits in its functioning. These data are suggestive of reduction in flexible cue utilization during aging, resulting paradoxically in more dependence on the hippocampus for aged rats than younger animals.